Lecture 8

Physiology, psychology, and memory models

Neural substrates of memory
Cortical organization
Neuropsychology of memory and amnesia
Synaptic modification
Redistribution of synaptic efficacy: What is a weight?

Schacter, Daniel L. (1996) Searching for Memory: The Brain, the Mind, and the Past. New York: Basic Books.
NOTE: This is an optional CN550 textbook. Try at least to skim it, reading sections that interest you.

Neural substrates of memory

• http://en.wikipedia.org/wiki/Cerebral_cortex

• Levine, Daniel S. (2000) Introduction to Neural and Cognitive Modeling. Hillsdale, NJ: Lawrence Erlbaum Associates, 2nd Edition.
  • Appendix 1: Basic Facts of Neurobiology, pp. 375–395
  • http://en.wikipedia.org/wiki/Neuron .

• Bear, Mark F., Connors, Barry W., and Paradiso, Michael A. (1996) Neuroscience: Exploring the Brain. Baltimore: Williams & Wilkins. Chapter 19: Memory systems, pp. 514-545. CC

Neuropsychology of memory and amnesia

• Clive Wearing: Living without memory YouTube (BBC – The Mind):
  • http://www.youtube.com/watch?v=Lu9UY8Zqg-Q&feature=related
  • http://www.youtube.com/watch?v=xCyvzI2aVUo&feature=related
  • http://www.youtube.com/watch?v=9BrCBq2FY_U&feature=related
  • http://www.youtube.com/watch?v=UKxr08GEE54&feature=related

• Hall, Stephen S. (1998) Our memories, our selves. The New York Times Magazine (February 15, 1998), 26-33, 49, 56-57. CC

• Corkin, Suzanne (2002) What’s new with the amnesic patient H.M.? Nature Reviews – Neuroscience, 3, 153-160. CC http://en.wikipedia.org/wiki/HM_%28patient%29

• Carey, Benedict (December 4, 2008) H.M., an unforgettable amnesiac, dies at 82. The New York TImes.

• Freedman, David J., Riesenhuber, Maximilian, Poggio, Tomaso, and Miller, Earl K. (2003) A comparison of primate prefrontal and inferior temporal cortices during visual categorization. Journal of Neuroscience, 23, 5235-5246.

• Holt, Jim, Numbers Guy The New Yorker, March 3, 2008, 42-47.

Synaptic modification

• http://en.wikipedia.org/wiki/Long-term_potentiation

• Kandel, Eric R., Schwartz, James H., and Jessell, Thomas P. (Eds.) (2000) Principles of Neural Science. 4th Edition. New York: McGraw-Hill.
  • Chapter 63: Eric R. Kandel. Cellular mechanisms of learning and the biological basis of individuality. pp. 1247–1279.

• Malenka, Robert C., and Nicoll, Roger A. (1999) Long-term potentiation – a decade of progress? Science, 285, 1870-1874. CC http://videocast.nih.gov/podcast.asp?13746

Redistribution of synaptic efficacy

• Markram, Henry, and Tsodyks, Misha (1996) Redistribution of synaptic efficacy between neocortical pyramidal neurons. Nature, 382, 807–810. CC
• Carpenter, Gail A. (2001) Neural network models of learning and memory: leading questions and an emerging framework. Trends in Cognitive Sciences, 5, 114-118. CC